Chemistry 125A: Freshman Organic Chemistry I - Lecture 18: Amide, Carboxylic Acid and Alkyl Lithium - Professor J. Michael McBride
Lecture 18 : Amide, Carboxylic Acid and Alkyl Lithium
This lecture completes the first half of the semester by analyzing three
functional groups in terms of the interaction of localized atomic or
pairwise orbitals. Many key properties of biological polypeptides derive
from the mixing of such localized orbitals that we associate with
"resonance" of the amide group. The acidity of carboxylic acids and the
aggregation of methyl lithium into solvated tetramers can be understood
in analogous terms. More amazing than the panoply of modern experimental
and theoretical tools is that their results would not have surprised
traditional organic chemists who already had developed an understanding
of organic structure with much cruder tools. The next quarter of the
semester is aimed at understanding how our scientific predecessors
developed the structural model and nomenclature of organic chemistry
that we still use.
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