
This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.
J. Michael McBride is the Richard M. Colgate Professor of Chemistry at Yale University. After undergraduate work at the College of Wooster and Harvard College Professor McBride earned a Ph.D. in physical organic chemistry at Harvard University. He joined the Yale Chemistry faculty in 1966, where he studies crystal growth and reactions in organic solids. His awards include the Prelog Medal, the Nobel Laureate Signature Award in Graduate Education, and the Catalyst Award of the Chemical Manufacturers Association for undergraduate education. Further details on his life, research, and teaching are available in Crystal Growth & Design, 2005, 5 (6), pp 2022–2035.
Note: Contents for this page are Licensed from http://oyc.yale.edu/ under the Creative Commons Attribution Share-Alike license.
| Lecture 1 | How Do You Know? |
| Lecture 2 | Force Laws, Lewis Structures and Resonance |
| Lecture 3 | Double Minima, Earnshaw's Theorem and Plum-Puddings |
| Lecture 4 | Coping with Smallness and Scanning Probe Microscopy |
| Lecture 5 | X-Ray Diffraction |
| Lecture 6 | Seeing Bonds by Electron Difference Density |
| Lecture 7 | Quantum Mechanical Kinetic Energy |
| Lecture 8 | One-Dimensional Wave Functions |
| Lecture 9 | Chladni Figures and One-Electron Atoms |
| Lecture 10 | Reality and the Orbital Approximation |
| Exam 1 | Midterm Exam 1 |
| Lecture 11 | Orbital Correction and Plum-Pudding Molecules |
| Lecture 12 | Overlap and Atom-Pair Bonds |
| Lecture 13 | Overlap and Energy-Match |
| Lecture 14 | Checking Hybridization Theory with XH3 |
| Lecture 15 | Chemical Reactivity: SOMO, HOMO, and LUMO |
| Lecture 16 | Recognizing Functional Groups |
| Lecture 17 | Reaction Analogies and Carbonyl Reactivity |
| Lecture 18 | Amide, Carboxylic Acid and Alkyl Lithium |
| Lecture 19 | Oxygen and the Chemical Revolution (Beginning to 1789) |
| Exam 2 | Midterm Exam 2 |
| Lecture 20 | Rise of the Atomic Theory (1790-1805) |
| Lecture 21 | Berzelius to Liebig and Wöhler (1805-1832) |
| Lecture 22 | Radical and Type Theories (1832-1850) |
| Lecture 23 | Valence Theory and Constitutional Structure (1858) |
| Lecture 24 | Determining Chemical Structure by Isomer Counting (1869) |
| Lecture 25 | Models in 3D Space (1869-1877); Optical Isomers |
| Lecture 26 | Van't Hoff's Tetrahedral Carbon and Chirality |
| Lecture 27 | Communicating Molecular Structure in Diagrams and Words |
| Lecture 28 | Stereochemical Nomenclature; Racemization and Resolution |
| Lecture 29 | Preparing Single Enantiomers and the Mechanism of Optical Rotation |
| Exam 3 | Midterm Exam 3 |
| Lecture 30 | Esomeprazole as an Example of Drug Testing and Usage |
| Lecture 31 | Preparing Single Enantiomers and Conformational Energy |
| Lecture 32 | Stereotopicity and Baeyer Strain Theory |
| Lecture 33 | Conformational Energy and Molecular Mechanics |
| Lecture 34 | Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes |
| Lecture 35 | Understanding Molecular Structure and Energy through Standard Bonds |
| Lecture 36 | Bond Energies, the Boltzmann Factor and Entropy |
| Lecture 37 | Potential Energy Surfaces, Transition State Theory and Reaction Mechanism |
| Exam 4 | Final Exam |
| Lectures | |
|---|---|
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 1: "How do you know?" - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 2: Force Laws, Lewis Structures and Resonance - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 3: Double Minima, Earnshaw's Theorem and Plum-Puddings - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 4: Coping with Smallness and Scanning Probe Microscopy - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 5: X-Ray Diffraction - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 6: Seeing Bonds by Electron Difference Density- Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 7: Quantum Mechanical Kinetic Energy - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 8: One-Dimensional Wave Functions - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 9: Chladni Figures and One-Electron Atoms - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 10: Reality and the Orbital Approximation - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 11: Orbital Correction and Plum-Pudding Molecules - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 12: Overlap and Atom-Pair Bonds - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 13: Overlap and Energy-Match - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 14: Checking Hybridization Theory with XH_3 - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 15: Chemical Reactivity: SOMO, HOMO, and LUMO - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 16: Recognizing Functional Groups - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 17: Reaction Analogies and Carbonyl Reactivity - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 18: Amide, Carboxylic Acid and Alkyl Lithium - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 19: Oxygen and the Chemical Revolution (Beginning to 1789) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 20: Rise of the Atomic Theory (1790-1805) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 21: Berzelius to Liebig and Wöhler (1805-1832) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 22: Radical and Type Theories (1832-1850) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 23: Valence Theory and Constitutional Structure (1858) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 24: Determining Chemical Structure by Isomer Counting (1869) - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 25: Models in 3D Space (1869-1877); Optical Isomers - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 26:Van't Hoff's Tetrahedral Carbon and Chirality - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 27: Communicating Molecular Structure in Diagrams and Words - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 28: Stereochemical Nomenclature; Racemization and Resolution - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 29: Preparing Single Enantiomers and the Mechanism of Optical Rotation - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 30: Esomeprazole as an Example of Drug Testing and Usage - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 31: Preparing Single Enantiomers and Conformational Energy - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 32: Stereotopicity and Baeyer Strain Theory - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 33: Conformational Energy and Molecular Mechanics - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 34: Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 35: Understanding Molecular Structure and Energy through Standard Bonds - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 36: Bond Energies, the Boltzmann Factor and Entropy - Professor J. Michael McBride | View |
| Chemistry 125A: Freshman Organic Chemistry I - Lecture 37: Potential Energy Surfaces, Transition State Theory and Reaction Mechanism - Professor J. Michael McBride | View |
| Description | Type | Link | |
|---|---|---|---|
| Final Exam | Download | Click |