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CHEM 125A: Freshman Organic Chemistry I

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  • Course Description

    This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

    About Professor J. Michael McBride

    J. Michael McBride is the Richard M. Colgate Professor of Chemistry at Yale University. After undergraduate work at the College of Wooster and Harvard College Professor McBride earned a Ph.D. in physical organic chemistry at Harvard University. He joined the Yale Chemistry faculty in 1966, where he studies crystal growth and reactions in organic solids. His awards include the Prelog Medal, the Nobel Laureate Signature Award in Graduate Education, and the Catalyst Award of the Chemical Manufacturers Association for undergraduate education. Further details on his life, research, and teaching are available in Crystal Growth & Design, 2005, 5 (6), pp 2022–2035.

    Note: Contents for this page are Licensed from http://oyc.yale.edu/ under the Creative Commons Attribution Share-Alike license.

    School
    Yale

    Course Code
    CHEM 125A

    Date Taught
    Fall 2008

    Level
    Undergraduate (First Year)


  • Lecture 1 How Do You Know?
    Lecture 2 Force Laws, Lewis Structures and Resonance
    Lecture 3 Double Minima, Earnshaw's Theorem and Plum-Puddings
    Lecture 4 Coping with Smallness and Scanning Probe Microscopy
    Lecture 5 X-Ray Diffraction
    Lecture 6 Seeing Bonds by Electron Difference Density
    Lecture 7 Quantum Mechanical Kinetic Energy
    Lecture 8 One-Dimensional Wave Functions
    Lecture 9 Chladni Figures and One-Electron Atoms
    Lecture 10 Reality and the Orbital Approximation
    Exam 1 Midterm Exam 1
    Lecture 11 Orbital Correction and Plum-Pudding Molecules
    Lecture 12 Overlap and Atom-Pair Bonds
    Lecture 13 Overlap and Energy-Match
    Lecture 14 Checking Hybridization Theory with XH3
    Lecture 15 Chemical Reactivity: SOMO, HOMO, and LUMO
    Lecture 16 Recognizing Functional Groups
    Lecture 17 Reaction Analogies and Carbonyl Reactivity
    Lecture 18 Amide, Carboxylic Acid and Alkyl Lithium
    Lecture 19 Oxygen and the Chemical Revolution (Beginning to 1789)
    Exam 2 Midterm Exam 2
    Lecture 20 Rise of the Atomic Theory (1790-1805)
    Lecture 21 Berzelius to Liebig and Wöhler (1805-1832)
    Lecture 22 Radical and Type Theories (1832-1850)
    Lecture 23 Valence Theory and Constitutional Structure (1858)
    Lecture 24 Determining Chemical Structure by Isomer Counting (1869)
    Lecture 25 Models in 3D Space (1869-1877); Optical Isomers
    Lecture 26 Van't Hoff's Tetrahedral Carbon and Chirality
    Lecture 27 Communicating Molecular Structure in Diagrams and Words
    Lecture 28 Stereochemical Nomenclature; Racemization and Resolution
    Lecture 29 Preparing Single Enantiomers and the Mechanism of Optical Rotation
    Exam 3 Midterm Exam 3
    Lecture 30 Esomeprazole as an Example of Drug Testing and Usage
    Lecture 31 Preparing Single Enantiomers and Conformational Energy
    Lecture 32 Stereotopicity and Baeyer Strain Theory
    Lecture 33 Conformational Energy and Molecular Mechanics
    Lecture 34 Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
    Lecture 35 Understanding Molecular Structure and Energy through Standard Bonds
    Lecture 36 Bond Energies, the Boltzmann Factor and Entropy
    Lecture 37 Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
    Exam 4 Final Exam
  • Lectures
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 1: "How do you know?" - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 2: Force Laws, Lewis Structures and Resonance - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 3: Double Minima, Earnshaw's Theorem and Plum-Puddings - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 4: Coping with Smallness and Scanning Probe Microscopy - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 5: X-Ray Diffraction - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 6: Seeing Bonds by Electron Difference Density- Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 7: Quantum Mechanical Kinetic Energy - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 8: One-Dimensional Wave Functions - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 9: Chladni Figures and One-Electron Atoms - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 10: Reality and the Orbital Approximation - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 11: Orbital Correction and Plum-Pudding Molecules - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 12: Overlap and Atom-Pair Bonds - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 13: Overlap and Energy-Match - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 14: Checking Hybridization Theory with XH_3 - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 15: Chemical Reactivity: SOMO, HOMO, and LUMO - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 16: Recognizing Functional Groups - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 17: Reaction Analogies and Carbonyl Reactivity - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 18: Amide, Carboxylic Acid and Alkyl Lithium - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 19: Oxygen and the Chemical Revolution (Beginning to 1789) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 20: Rise of the Atomic Theory (1790-1805) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 21: Berzelius to Liebig and Wöhler (1805-1832) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 22: Radical and Type Theories (1832-1850) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 23: Valence Theory and Constitutional Structure (1858) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 24: Determining Chemical Structure by Isomer Counting (1869) - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 25: Models in 3D Space (1869-1877); Optical Isomers - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 26:Van't Hoff's Tetrahedral Carbon and Chirality - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 27: Communicating Molecular Structure in Diagrams and Words - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 28: Stereochemical Nomenclature; Racemization and Resolution - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 29: Preparing Single Enantiomers and the Mechanism of Optical Rotation - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 30: Esomeprazole as an Example of Drug Testing and Usage - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 31: Preparing Single Enantiomers and Conformational Energy - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 32: Stereotopicity and Baeyer Strain Theory - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 33: Conformational Energy and Molecular Mechanics - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 34: Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 35: Understanding Molecular Structure and Energy through Standard Bonds - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 36: Bond Energies, the Boltzmann Factor and Entropy - Professor J. Michael McBride View
    Chemistry 125A: Freshman Organic Chemistry I - Lecture 37: Potential Energy Surfaces, Transition State Theory and Reaction Mechanism - Professor J. Michael McBride View
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