International Year of Chemistry, 2011

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International Year of Chemistry 2011

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Categorizing Halogen Bonding and other Noncovalent Interactions Involving Halogen Atoms

Activity by Pierangelo Metrangolo   |   added on Mar 07, 2011   |   Italy Official_iyc_logo

Sponsor(s): IUPAC, CrystEngComm, Chem. Commun., Cryst. Growth Des.

The meeting “Categorizing Halogen Bonding and Other Noncovalent Interactions Involving Halogen Atoms” will be held in Sigüenza, Guadalajara, Spain on August 20-21, 2011, as a satellite event to the IUCr2011 (Madrid) and under the sponsorship of the IUPAC.

Halogen atoms in organic compounds typically can be found at the periphery of molecules. For this reason, they are ideally positioned to be involved in intermolecular interactions. For instance, halogen atoms are commonplace substituents in  drugs and also occur naturally in biological systems, the best-known examples being probably the iodinated thyroid hormones, such as thyroxine. Indeed, interactions involving halogen atoms are frequently observed in protein-ligand complexes.

It is well-known that the electron density around the halogen nucleus is highly anisotropic so that halogens can serve both as electron-acceptors and -donors. The term halogen bonding has been introduced for describing any noncovalent interaction involving halogens as acceptors of electron density. The general scheme D···X-Y thus applies to halogen bonding (XB), wherein X is the halogen (Lewis acid, XB-donor), D is any electron-donor (Lewis base, XB-acceptor), and Y is carbon, halogen, nitrogen, etc. The definition itself sheds light on the nature of XB, which possesses numerous similarities with hydrogen bonding (HB), wherein hydrogen functions as the acceptor of electron density.

The objective of this meeting is to gather several international leaders in the field around the task of giving a modern definition of halogen bonding that takes into account all current experimental and theoretical pieces of information on both gaseous and condensed halogen-bonded systems in chemical and biological systems.


Topic: chemistry education, conferences Audience: students, professional chemists, professors, industrial chemists, research scientists, universities
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