Exploring Chemical Space: Synthesising the Drugs of Tomorrow
Activity by Jacqui Colgate | added on Jan 31, 2011 | United Kingdom
Sponsor(s):
Organic chemistry is dominated by a remarkably small number of molecular scaffolds. Therefore, the exploration of novel chemical space and molecular diversity remains a fundamental task for academic, pharmaceutical, and agrochemical researchers.
SCI HQ, London, UK
23 March 2011, 10.00 - 17.30
Organised by SCI's Fine Chemicals Group
Organic chemistry is dominated by a remarkably small number of molecular scaffolds. Therefore, the exploration of novel chemical space and molecular diversity remains a fundamental task for academic, pharmaceutical, and agrochemical researchers.
A recent analysis of chemical literature demonstrated that many areas of chemical space still remain unexploited, thus accentuating the need for a fresh drive towards finding novel chemical frameworks. A key challenge for chemists involved in pharmaceutical or agrochemical research is to develop new virtual and synthetic methods to enable a more thorough exploration of potentially relevant chemical space.
This meeting will bring together speakers from industry and academia to present the latest approaches towards defining novel biologically active entities, seeding ideas across the synthetic/medicinal chemistry border. There will also be discussions of new synthetic techniques, such as diversity-orientated synthesis, that can be used to exploit previously untapped areas of chemical space and thus aid in the search for the pharmaceuticals and agrochemicals of tomorrow.
Who should attend?This meeting is targeted at chemists working in agrochemicals, medicinal chemistry and chemical biology, especially those involved in the hit identification and lead optimization processes. It should also attract people from academic synthesis groups and chemo-informaticians working in related areas.
ProgrammePlease click here to view the full programme.
10.00
Registration and refreshments
10.30
What should we make next? Ideas from computational studies of aromatic rings in Nature and from the lab
William Pitt, UCB, UK
11.15
Development of synthetic approaches for the systematic exploration of chemical space
Adam Nelson, University of Leeds, UK
12.00
Design and exploitation of novel medicinal chemistry reagent sets
Jason Kettle, AstraZeneca, UK
Lunch
13.30
Moving in new circles - exploiting macrocycles for drug discovery
Nicholas Terrett, Ensemble Therapeutics, Cambridge, USA
Diversity-oriented synthesis
David Spring, University of Cambridge, UK
15.00
Medicinally relevant chemical space and consequences for synthesis
Michael Waring, AstraZeneca, UK
Refreshement break
15.50
The synthetic challenges of accessing new design space
Nicholas Summerhill, Pfizer, UK
Design and synthesis of kinase inhibitors using novel heterocyclic systems
Steven Durrant, Vertex, UK
Strategies and tactics in the synthesis of natural product-based libraries
Derek S. Tan, Memorial Sloan-Kettering Cancer Center, NY, USA
Closing remarks
17.30Wine reception
Organising Committee
Liam Cox, University of Birmingham
Keith Jones, Institute of Cancer Research
Ray Jones, Loughborough University
Sarah Major, Argenta
Nat Monck, Cancer Research Technology
SCI HQ, London, UK
Please click here for a location map.
Please note fees include the 5% discount for making an online booking
Earlybird fees - before 23 February
GB£94.00 . . . . . . . . . SCI Member
GB£33.00. . . . . . . . . .SCI Student Member
GB£66.50 . . . . . . . . . SCI Subsidised Member
GB£138.00 . . . . . . . . . Non Member
Standard fees - after 23 February
GB£113.00 . . . . . . . . . SCI Member
GB£40.00 . . . . . . . . . SCI Student
GB£80.00 . . . . . . . . . SCI Subsidised Member
GB£165.00 . . . . . . . . . Non Member
Conference Team
T: +44 (0)20 7598 1561
F: +44 (0)20 7235 7743
E: conferences@soci.org
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