Chemistry 2011.org
Chemistry2011.org
All About Chemistry... 2011 and beyond

Related Stories

Test of new device that protects brain during heart-valve procedure

In the first multicenter trial of its kind, Yale researchers tested a new device that lowers the risk of stroke and cognitive decline in patients undergoing heart-valve replacement.

The preliminary findings of the DEFLECT III trial were presented by Alexandra Lansky, M.D., associate professor of medicine (cardiology) at Yale School of Medicine, on March 15 at the American College of Cardiology's 64th Annual Scientific Session in San Diego, CA.

Stroke is a devastating complication of transcatheter aortic valve replacement (TAVR), a minimally invasive procedure to repair a damaged heart valve without surgery. Up to 7% of TAVR patients suffer strokes due to the release of emboli, or particulate material such as a plaque, that travel in the blood from the heart to the brain during the valve procedure.

Led by co-principal investigators Lansky and Andreas Baumbach, M.D. of Bristol Heart Institute, the research team conducted a preliminary trial of the TriGuard, a device that is placed in the aortic arch during TAVR. The device has a mesh filter that covers the three major cerebral blood vessels, preventing the release of emboli from the aorta to the brain.

Conducted in centers in Europe and Israel, the exploratory trial enrolled 83 subjects and randomized them for TAVR with and without TriGuard protection. In patients with protection, the researchers observed fewer ischemic brain lesions and lesions of reduced volume.

"One of the major findings is, for the first time, we're showing that with protection, 55% more patients have completely clean brains -- with no ischemic brain lesions at all," said Lansky. Brain lesions increase risk of dementia and stroke two- to three-fold.

"What's more exciting are the neurocognitive findings," noted Lansky. The researchers used the Montreal Cognitive Assessment (MoCA) to evaluate the impact of TriGuard on cognitive factors such as language, memory, attention, recall, and orientation. "Whether we're looking at MoCA or looking at short-term memory or delayed memory, we're seeing an improvement in cognitive function as early as hospital discharge among protected patients, compared to controls," she explained.

These preliminary findings provide the basis to design a conclusive randomized clinical trial. "DEFLECT III is helping us design the next study, which will be definitive," Lansky noted.

Story Source:

The above story is based on materials provided by Yale University. The original article was written by Ziba Kashef. Note: Materials may be edited for content and length.

Share this story with your friends!

Social Networking

Please recommend us on Facebook, Twitter and more:

Other social media tools

Global Partners
Feedback

Tell us what you think of Chemistry 2011 -- we welcome both positive and negative comments. Have any problems using the site? Questions?

About us

Chemistry2011 is an informational resource for students, educators and the self-taught in the field of chemistry. We offer resources such as course materials, chemistry department listings, activities, events, projects and more along with current news releases.

Events & Activities

Are you interested in listing an event or sharing an activity or idea? Perhaps you are coordinating an event and are in need of additional resources? Within our site you will find a variety of activities and projects your peers have previously submitted or which have been freely shared through creative commons licenses. Here are some highlights: Featured Idea 1, Featured Idea 2.

About you

Ready to get involved? The first step is to sign up by following the link: Join Here. Also don’t forget to fill out your profile including any professional designations.

Global Partners