Using high-performance computers, the research team from Curtin and Los Alamos National Laboratory were able to show radioactivity could alter molecular structures which encode genetic information, creating new molecules that do not belong to the four-letter alphabet of DNA.
Professor Nigel Marks from Curtin's Discipline of Physics and Astronomy and Curtin's Nanochemistry Research Institute said the new molecules may well generate mutations by confusing the replication mechanisms in DNA.
"We have discovered a subtle process that could easily be overlooked by the standard cell repair mechanisms in the body, potentially creating a new pathway for mutations to occur."
Professor Marks said the work was both exciting and unexpected, emerging as a spin-off from an Australian Research Council funded project on nuclear waste.
"As part of the project between Curtin and Los Alamos we developed a suite of computational tools to examine deliberate radioactivity in crystalline solids, only to later realise that the same methods could be applied to natural radioactivity in molecules," he said.
"This direction was an unplanned outcome of our research program -- just the way blue skies research should be."
Professor Marks said this was one of the most abundant forms of radioactive decay occurring in Biological-Systems'>biological systems. Over a human lifetime, around 50 billion Carbon-14 decays occur within our DNA.
"While it is still not obvious how DNA replication is affected by the presence of chemical compounds that are different to the four-letter alphabet of DNA, it is quite remarkable to consider that Carbon-14 could be a source of genetic mutation that would be impossible to avoid due to the universal presence of radiocarbon in the environment," Professor Marks said.
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