Chemistry 2011.org
Chemistry2011.org
All About Chemistry... 2011 and beyond

Related Stories

Prenatal phthalate exposures and anogenital distance in swedish boys

The first study to examine prenatal exposure to the phthalate DiNP finds it is associated with a shorter anogenital distance (AGD) in Swedish boys at the age of 21 months. These findings raise concern since animal research has linked DiNP exposure to a shorter AGD, and studies on humans have related shorter AGD to male genital birth defects as well as impaired reproductive function in adult males, and the levels of DiNP metabolites in humans are increasing globally.

Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and found in a large number of commonly used consumer products. Due to reported health risk, di-isononyl phthalate (DiNP) has been introduced as a replacement for diethyl hexyl phthalate (DEHP) as a plasticizer in soft PVC. This raises concerns since animal data suggest that DiNP may have anti-androgenic properties similar to DEHP. In addition, biomonitoring data show that human DiNP metabolite levels are rapidly increasing globally. The anogenital distance (AGD) -- the distance from the anus to the genitals -- is a marker that has been used in animal studies to assess reproductive toxicity. While several studies have examined phthalates such as DBP, DEHP and AGD in humans, none has included DiNP.

The purpose of the current study have been to examine the relationship between 1st trimester urinary metabolite concentrations (week 9-11) of DEP, DBP, DEHP, BBzP as well as DiNP in relation to AGD in 196 Swedish boys at 21 months of age. Analyzes of the mothers urine, identified all phthalate metabolites in all samples. Anogenital distance was measured by two pediatric nurses at County Council of Värmland, Sweden. The measured phthalate levels and AGD were comparable with data from two pregnancy cohort studies in USA.

Most of the phthalate metabolites were associated with a shorter AGD, however, not all associations reached significance. The strongest and significant associations were found between a shorter AGD and DiNP metabolites.

These findings call into question the safety of the recent substitution of DiNP for DEHP in soft PVC, particularly since a shorter male AGD has been shown to be related to male genital birth defects in children (such as hypospadias and undescended testis) and impaired reproductive function in adult males (such as decreased fertility, impaired semen quality and lower serum testosterone levels) and the fact that human levels of DiNP are rapidly increasing globally, says Carl-Gustaf Bornehag, professor in Public Health Sciences at Karlstad University and responsible for the current study.

Story Source:

The above story is based on materials provided by Expertsvar. Note: Materials may be edited for content and length.

Share this story with your friends!

Social Networking

Please recommend us on Facebook, Twitter and more:

Other social media tools

Global Partners
Feedback

Tell us what you think of Chemistry 2011 -- we welcome both positive and negative comments. Have any problems using the site? Questions?

About us

Chemistry2011 is an informational resource for students, educators and the self-taught in the field of chemistry. We offer resources such as course materials, chemistry department listings, activities, events, projects and more along with current news releases.

Events & Activities

Are you interested in listing an event or sharing an activity or idea? Perhaps you are coordinating an event and are in need of additional resources? Within our site you will find a variety of activities and projects your peers have previously submitted or which have been freely shared through creative commons licenses. Here are some highlights: Featured Idea 1, Featured Idea 2.

About you

Ready to get involved? The first step is to sign up by following the link: Join Here. Also don’t forget to fill out your profile including any professional designations.

Global Partners